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Studies on the Abortion-Breast Cancer Link

Research Synthesis: Induced Abortion and Breast Cancer

No. Year Reference OR or RR (95% CI) Statistically Significant Positive or Negative Correlation Country or Population
1 1957 M. Segi, I. Fukushima, S. Fujisaku, M. Kurihara, S. Saito, K. Asano, and M. Kamoi, “An Epidemiological Study on Cancer in Japan,” Japanese Journal of Cancer Research (GANN) 48 (Suppl.) (1957): 1-63. 2.63 (1.85-3.75)* Yes Positive Japan
2 1968 H. Watanabe and T. Hirayama, “Epidemiology and Clinical Aspects of Breast Cancer,” Nippon Rinsho 26 (1968): 1843-1849 (in Japanese). 1.51 (0.91-2.53)* No Positive Japan
3 1978 V.V. Dvoirin and A.B. Medvedev, “Role of Women’s Reproductive Status in the Development of Breast Cancer,” in Methods and Progress in Breast Cancer Epidemiology Research, by Tallin (Moscow: Oncology Science Center of the USSR Academy of Sciences, 1978), 53-63 (in Russian). 1.71 (0.80-3.64)* No Positive USSR/ Estonia
4 1979 B. Burany, “Gestational characteristics in women with breast cancer,” Jugosil Ginekol Opstet 19 (1979):237-247 (in Serbo-Croatian). 0.50 (0.33-0.74)* Yes Negative Yugoslavia
5 1981 M.C. Pike, B.E. Henderson, J.T. Casagrande, I. Rosario, and G.E. Gray, “Oral Contraceptive Use and Early Abortion as Risk Factors for Breast Cancer in Young Women,” British Journal of Cancer 43, no. 1 (1981): 72-76. 2.37 (0.85-6.93)* No Positive United States
6 1982 F. Nishiyama, “The Epidemiology of Breast Cancer in Tokushima Prefecture,” Shikoku Ichi 38 (1982): 333-343 (in Japanese). 2.52 (1.99-3.20)* Yes Positive Japan
7 1983 L.A. Brinton, R. Hoover, and J.F. Fraumeni, Jr., “Reproductive factors in the aetiology of breast cancer,” British Journal of Cancer 47, no. 6 (1983): 757-762. 1.34 (.3-5.6) if before first live birth; .89 (.4-2.00) if after first live birth; 5.5 (.8-36.8) if nulliparous No Positive/ Negative/ Positive United States
8 1984 Monique G. Lê, Annie Bacheloti, F. Doyon, A. Kramar, and Catherine Hill, “Oral Contraceptive Use and Breast or Cervical Cancer: Preliminary Results of a French Case-Control Study,” in Hormones and Sexual Factors in Human Cancer Aetiology, eds. J.P Wolff and J.S. Scott (Amsterdam: Elsevier, 1984), 139-147. 1.32 (0.97-1.77)* No Positive France
9 1985 T. Hirohata, T. Shigematsu, A.M. Nomura, Y. Nomura, A. Horie, and I. Hirohata, “Occurrence of breast cancer in relation to diet and reproductive history: a case-control study in Fukuoka, Japan,” National Cancer Institute Monograph 69 (1985): 187-190. 1.52 (0.93-2.48) No Positive Japan
10 1987 C. La Vecchia, A. Decarli, F. Parazzini, A. Gentile, E. Negri, G. Cecchetti, and S. Franceschi, “General epidemiology of breast cancer in northern Italy,” International Journal of Epidemiology16, no. 3 (1987): 347-355. 1.19 (0.82-1.71) if 1 IA; .78 (.52-1.13) if ≥2 IA No Positive/ Negative Italy
11 1988 M. Ewertz and S.W. Duffy, “Risk of breast cancer in relation to reproductive factors in Denmark,” British Journal of Cancer 58, no. 1 (1988): 99-104. 3.85 (1.08-13.6) with IA in nulliparous women Yes Positive Denmark