This is an old revision of the document!


Studies on the Abortion-Breast Cancer Link

Research Synthesis: Induced Abortion and Breast Cancer

No. Year Reference OR or RR (95% CI) Statistically Significant Positive or Negative Correlation Country or Population
1 1957 M. Segi, I. Fukushima, S. Fujisaku, M. Kurihara, S. Saito, K. Asano, and M. Kamoi, “An Epidemiological Study on Cancer in Japan,” Japanese Journal of Cancer Research (GANN) 48 (Suppl.) (1957): 1-63. 2.63 (1.85-3.75)* Yes Positive Japan
2 1968 H. Watanabe and T. Hirayama, “Epidemiology and Clinical Aspects of Breast Cancer,” Nippon Rinsho 26 (1968): 1843-1849 (in Japanese). 1.51 (0.91-2.53)* No Positive Japan
3 1978 V.V. Dvoirin and A.B. Medvedev, “Role of Women’s Reproductive Status in the Development of Breast Cancer,” in Methods and Progress in Breast Cancer Epidemiology Research, by Tallin (Moscow: Oncology Science Center of the USSR Academy of Sciences, 1978), 53-63 (in Russian). 1.71 (0.80-3.64)* No Positive USSR/ Estonia
4 1979 B. Burany, “Gestational characteristics in women with breast cancer,” Jugosil Ginekol Opstet 19 (1979):237-247 (in Serbo-Croatian). 0.50 (0.33-0.74)* Yes Negative Yugoslavia
5 1981 M.C. Pike, B.E. Henderson, J.T. Casagrande, I. Rosario, and G.E. Gray, “Oral Contraceptive Use and Early Abortion as Risk Factors for Breast Cancer in Young Women,” British Journal of Cancer 43, no. 1 (1981): 72-76. 2.37 (0.85-6.93)* No Positive United States
6 1982 F. Nishiyama, “The Epidemiology of Breast Cancer in Tokushima Prefecture,” Shikoku Ichi 38 (1982): 333-343 (in Japanese). 2.52 (1.99-3.20)* Yes Positive Japan
7 1983 L.A. Brinton, R. Hoover, and J.F. Fraumeni, Jr., “Reproductive factors in the aetiology of breast cancer,” British Journal of Cancer 47, no. 6 (1983): 757-762. 1.34 (.3-5.6) if before first live birth; .89 (.4-2.00) if after first live birth; 5.5 (.8-36.8) if nulliparous No Positive/ Negative/ Positive United States
8 1984 Monique G. Lê, Annie Bacheloti, F. Doyon, A. Kramar, and Catherine Hill, “Oral Contraceptive Use and Breast or Cervical Cancer: Preliminary Results of a French Case-Control Study,” in Hormones and Sexual Factors in Human Cancer Aetiology, eds. J.P Wolff and J.S. Scott (Amsterdam: Elsevier, 1984), 139-147. 1.32 (0.97-1.77)* No Positive France
9 1985 T. Hirohata, T. Shigematsu, A.M. Nomura, Y. Nomura, A. Horie, and I. Hirohata, “Occurrence of breast cancer in relation to diet and reproductive history: a case-control study in Fukuoka, Japan,” National Cancer Institute Monograph 69 (1985): 187-190. 1.52 (0.93-2.48) No Positive Japan
10 1987 C. La Vecchia, A. Decarli, F. Parazzini, A. Gentile, E. Negri, G. Cecchetti, and S. Franceschi, “General epidemiology of breast cancer in northern Italy,” International Journal of Epidemiology16, no. 3 (1987): 347-355. 1.19 (0.82-1.71) if 1 IA; .78 (.52-1.13) if ≥2 IA No Positive/ Negative Italy
11 1988 M. Ewertz and S.W. Duffy, “Risk of breast cancer in relation to reproductive factors in Denmark,” British Journal of Cancer 58, no. 1 (1988): 99-104. 3.85 (1.08-13.6) with IA in nulliparous women Yes Positive Denmark
12 1988 E. Luporsi, “Breast cancer and alcohol,” (PhD thesis, University of Paris-Sud, 1988), data in N. Andrieu, S.W. Duffy, T.E. Rohan, M.G. Lê, E. Luporsi, M. Gerber, R. Renaud, D.G. Zaridze, Y. Lifanova, and N.E. Day, “Familial Risk, Abortion and Their Interactive Effect on the Risk of Breast Cancer—A Combined Analysis of Six Case-Control Studies,” British Journal of Cancer 72, no. 3 (1995): 744-751. 1.8 (1.0-3.5) if 1 IA; 1.9 (.5-6.9) if ≥2 IA Marginal/ No Positive France
13 1988 D.G. Zaridze data (unpublished) in N. Andrieu, S.W. Duffy, T.E. Rohan, M.G. Lê, E. Luporsi, M. Gerber, R. Renaud, D.G. Zaridze, Y. Lifanova, and N.E. Day, “Familial Risk, Abortion and Their Interactive Effect on the Risk of Breast Cancer—A Combined Analysis of Six Case-Control Studies,” British Journal of Cancer 72, no. 3 (1995): 744-751. 1.0 (.7-1.4) if 1 IA; .7 (.6-1.0) if ≥2 IA No/ Marginal Null/ Negative Russia
14 1984 M.G. Lê, A. Bachelot, F. Doyon, A. Kramar, and C. Hill, “Oral Contraceptive Use and Breast Cancer or Cervical Cancer: Preliminary Results of a French Case-Control Study,” in Hormones and Sexual Factors in Human Cancer Aetiology, eds. J-P Wolff and J.D. Scott (Amsterdam: Elsevier Science, 1984), data in N. Andrieu, S.W. Duffy, T.E. Rohan, M.G. Lê, E. Luporsi, M. Gerber, R. Renaud, D.G. Zaridze, Y. Lifanova, and N.E. Day, “Familial Risk, Abortion and Their Interactive Effect on the Risk of Breast Cancer—A Combined Analysis of Six Case-Control Studies,” British Journal of Cancer 72, no. 3 (1995): 744-751. 1.2 (.7-2.1) if 1 IA; 1.9 (1.0-3.6) if ≥2 IA No/ Marginal Positive France
15 1988 T. Rohan, A.J. McMichael, and P.A. Baghurst, “A population-based case-control study of diet and breast cancer in Australia,” American Journal of Epidemiology 128 (1988): 478-489, data in N. Andrieu, S.W. Duffy, T.E. Rohan, M.G. Lê, E. Luporsi, M. Gerber, R. Renaud, D.G. Zaridze, Y. Lifanova, and N.E. Day, “Familial Risk, Abortion and Their Interactive Effect on the Risk of Breast Cancer—A Combined Analysis of Six Case-Control Studies,” British Journal of Cancer 72, no. 3 (1995): 744-751. 2.7 (1.1-6.7) if 1 IA; 2.2 (.4-12.0) if ≥2 IA Yes/ No Positive Australia
16 1988 Lynn Rosenberg, Julie R. Palmer, David W. Kaufman, Brian L. Strom, David Schottenfeld, and Samuel Shapiro, “Breast Cancer in Relation to the Occurrence and Time of Induced and Spontaneous Abortion,” American Journal of Epidemiology 127 (1988): 981-989. 1.2 (.9-1.6) if parous; 1.3 (.8-2.2) if nulliparous No Positive United States
17 1989 B.M. Lindefors Harris, G. Eklund, O. Meirik, L.E. Rutqvist, and K. Wiklund, “Risk of cancer of the breast after legal abortion during first trimester: a Swedish register study,” British Medical Journal 299, no. 6713 (1989): 1430-1432. 0.77 (0.58-0.99) Yes Negative
18 1989 Holly L. Howe, Ruby T. Senie, Helen Bzduch, and Peter Herzfeld, “Early Abortion and Breast Cancer Risk Among Women Under Age 40,” International Journal of Epidemiology 18 (1989): 300-304. 1.9 (1.2-3.0) Yes Positive United States
19 1989 Larissa I. Remennick, “Reproductive Patterns and Cancer Incidence in Women: A Population-Based Correlation Study in the USSR,” International Journal of Epidemiology 18, no. 3 (September 1989): 498-510. data not in the form of OR Yes Positive USSR